What is Lu PSMA (Lutetium-Prostate Specific Membrane Antigen) Therapy?

Lu177 PSMA Therapy is a treatment for patients with prostate cancer, especially those who have become refractory to conventional therapy. Lutetium PSMA therapy helps to slow down the growth of the cancer cells, reduce the size of the tumours and most importantly improve the quality of life of the patients by reducing the pain caused by the cancer.

Many prostate cancers, in particular those that have spread or become resistant to hormonal therapies, express a unique receptor on their cell surface called Prostate Specific Membrane Antigen (PSMA). When Prostate Cancer metastasizes i.e. spreads to other parts of the body, the PSMA receptor is expressed over the sites of metastases as well.

How does Lu PSMA Therapy Work?

Lutetium-177 is a radioactive substance that emits beta radiation, a destructive kind of radiation. Lutetium-177 is bound to a small peptide which attaches to the PSMA receptor expressed on the cancer cell surface. The Lutetium 177 – PSMA complex, thus attached to the prostate cancer cell, then emits killing radiation causing cell death of the cancer cell. Since the penetration of the emitted beta particle is very small, the surrounding normal cells are spared.

How is the Therapy Done?

Lu177 PSMA is administered intravenously. The patient is admitted to the hospital for 24 hours. A kidney function scan called a MAG3/EC scan is done prior to the administration of the Lu177 PSMA.

What are the Side Effects of Lu PSMA Therapy?

Lu177 PSMA is well tolerated. The most common side effects are a slightly dry mouth, fatigue and nausea. There may also be a slight fall in the white blood cells and platelets about 2 – 3 weeks after the Lu177 PSMA administration.

What is the Response Rate With Lu PSMA Therapy?

The response rates of Lu177 PSMA depend on the tumour biology of prostate cancer, the initial Gleason Score, the extent of disease and the responses to prior therapies. Typically, more than 70% of patients demonstrate a reduction in S. PSA and a shrinkage of tumours following Lu177 PSMA therapy.

When would the doctor consider using this Therapy?

Lu PSMA Therapy is a very specific therapy and is used for managing metastatic Prostate Cancer or when Prostate Cancer is no longer responsive to other types of treatment.

What are the Treatment Schedules with Lu PSMA Therapy?

Most patients undergo three-four treatment cycles at intervals of 8-12 weeks. The number of cycles and the interim duration may vary between individuals depending on the response and interim assessments.

Why should I choose the nuclear medicine therapy center at Fortis Memorial & Research Institute (FMRI), Gurugram (Haryana, India)?

The Nuclear Medicine Therapy Centre at FMRI was one of the first institutes to offer Radio-ligand Therapy with Lu PSMA, and today, the center receives patients from the country and from across the world.

From Awareness to Action: How Prostate Cancer Month Can Save Lives

Summary (10 sec read)

Prostate Cancer Awareness Month in September emphasizes education and early detection. Advancements in nuclear medicine offer precise diagnosis and treatment, improving patient outcomes and providing hope for those affected.

September is Prostate Cancer Awareness Month, a time dedicated to shining a spotlight on one of the most common cancers affecting men worldwide. Prostate cancer, second only to skin cancer in prevalence, impacts millions of men each year. This staggering occurrence underscores the need for increased awareness, education, and the integration of cutting-edge diagnostics, particularly in nuclear medicine, to enhance patient outcomes.

Activities During Prostate Cancer Awareness Month

Throughout September, a variety of activities are organized globally to raise awareness and educate men about prostate cancer:

1. Public Awareness Campaigns:

Major health organizations and advocacy groups launch extensive public awareness campaigns through television, radio, social media, and community events. These campaigns aim to inform men about prostate cancer risk factors, symptoms, and the critical importance of regular screening.

For instance, the Prostate Cancer Foundation runs the "Know Your Numbers" campaign, encouraging men to learn about their PSA (Prostate-Specific Antigen) levels as a key indicator of prostate health.

2. Blue Ribbon Events:

The blue ribbon, the symbol for prostate cancer awareness, is widely promoted during events such as community walks, runs, and bike rides. These events not only raise funds for research but also bring communities together to show support for those affected by the disease.

The "Run for Dad" events across various cities are popular examples, combining physical activity with fundraising for prostate cancer research.

3. Educational Workshops and Webinars:

Hospitals and clinics host seminars, workshops, and webinars led by healthcare professionals. These events provide the latest information on prostate cancer detection, treatment advancements, and management strategies, including discussions on the role of nuclear medicine in precise diagnosis and staging.

Online platforms like the American Urological Association offer free webinars, making it easier for men to access valuable information from the comfort of their homes.

4. Support Group Initiatives:

- Special efforts are made to connect newly diagnosed patients with support groups, offering them and their families emotional support and practical advice. Organizations such as Us TOO International organize virtual and in-person meetings where patients can share experiences and gain insights from others facing similar challenges.

Global Doctors on the Importance of Prostate Cancer Awareness

Healthcare professionals around the world emphasize the critical importance of Prostate Cancer Awareness Month in the battle against this disease:

Dr. Charles Ryan, CEO of the Prostate Cancer Foundation, stated, "Prostate Cancer Awareness Month is an essential time for us to educate men about their health. Early detection is crucial, and with the advancements in diagnostic tools, particularly in nuclear medicine, we have more power than ever to detect and treat prostate cancer effectively."

Dr. Heather Payne, a leading oncologist at University College Hospital in London, added, "The stigma and fear associated with prostate cancer often lead to delayed diagnosis. Prostate Cancer Awareness Month provides a platform to break down these barriers, encouraging men to seek timely medical advice and benefit from the latest in treatment options."

Dr. Stephen Freedland, a renowned urologist at Cedars-Sinai Medical Center in Los Angeles, commented, "Education is the cornerstone of prostate cancer prevention and treatment. The more men know about their risks and the benefits of early screening, the better we can manage this disease. Awareness months like this are critical in spreading that knowledge."

Dr. Ishita B. Sen, who heads the Molecular Imaging and Nuclear Oncology Department at Fortis Memorial Research Institute (FMRI) in Gurgaon (Delhi NCR), offered a hopeful perspective: "With the latest advancements in nuclear medicine, we are now able to diagnose and treat prostate cancer with remarkable precision. These treatments are not only extending lives but also significantly improving the quality of life for our patients. There's every reason for hope—patients today have access to therapies that were unimaginable a few years ago, and many are living full, active lives despite a prostate cancer diagnosis."

Also Read

Understanding Neuroendocrine Tumors and their symptoms by Dr. Ishita B Sen

Can you live for 20 years after prostate removal?

From Awareness to Action: How Prostate Cancer Month Can Save Lives

Frequently Asked Questions

What is the significance of Prostate Cancer Awareness Month?

Prostate Cancer Awareness Month serves as a dedicated time to raise awareness about the disease, educate the public on its risk factors and symptoms, and encourage men to seek timely screenings and medical advice. It plays a crucial role in promoting early detection and empowering individuals to take proactive steps towards their health.
What are some common activities organized during Prostate Cancer Awareness Month?

Various activities take place globally during this month, including:
- Public awareness campaigns through various media channels
- Blue Ribbon events, such as walks and runs, to raise funds for research
- Educational workshops and webinars led by healthcare professionals
- Support group initiatives to connect patients and their families
How has nuclear medicine contributed to advancements in prostate cancer diagnosis and treatment?

Nuclear medicine techniques offer precise imaging and staging, enabling doctors to better understand the extent of the disease and tailor treatments accordingly. Targeted therapies using radioactive substances can deliver radiation directly to cancer cells, minimizing damage to healthy tissue. These advancements enhance treatment accuracy and improve patient outcomes.
What are some encouraging messages from healthcare professionals about prostate cancer?

Doctors worldwide emphasize the importance of early detection and the positive impact of new treatments. They stress that with advancements in diagnostics and therapies, there's reason for hope, and many patients are living full, active lives after a prostate cancer diagnosis.
How can I get involved in Prostate Cancer Awareness Month?

You can contribute by:
- Participating in local awareness events or fundraisers
- Sharing information about prostate cancer on social media
- Encouraging men in your life to talk to their doctors about screening
- Donating to prostate cancer research organizations

Consult Dr Ishita B Sen

Your Name (required)

Your Email (required)

Phone Number (required)

Upload your Reports(Max file size 20mb)

Medical History

captcha

[Type Security code here]