Do All Prostate Cancers Express PSMA
Patients ask me do all prostate cancers express PSMA so yes most of the well differentiated or differentiated prostate cancers will express PSMA And the more aggressive the prostate cancer the more high grade the prostate cancer the higher the expression of PSMA The only caveat is that there are some tumors which express a neuroendocrine differentiation So this is a kind of prostate cancer which while it arises in the prostate gland may have a certain different kind of differentiation and the neuroendocrine differentiated prostate cancers do not express PSMA So as the prostate cancer becomes more aggressive the PSMA expression increases and this gives us an optimum target to treat these patients of prostate cancer.