What is Lu PSMA (Lutetium-Prostate Specific Membrane Antigen) Therapy?

Lu177 PSMA Therapy is a treatment for patients with prostate cancer, especially those who have become refractory to conventional therapy. Lutetium PSMA therapy helps to slow down the growth of the cancer cells, reduce the size of the tumours and most importantly improve the quality of life of the patients by reducing the pain caused by the cancer.

Many prostate cancers, in particular those that have spread or become resistant to hormonal therapies, express a unique receptor on their cell surface called Prostate Specific Membrane Antigen (PSMA). When Prostate Cancer metastasizes i.e. spreads to other parts of the body, the PSMA receptor is expressed over the sites of metastases as well.

How does Lu PSMA Therapy Work?

Lutetium-177 is a radioactive substance that emits beta radiation, a destructive kind of radiation. Lutetium-177 is bound to a small peptide which attaches to the PSMA receptor expressed on the cancer cell surface. The Lutetium 177 – PSMA complex, thus attached to the prostate cancer cell, then emits killing radiation causing cell death of the cancer cell. Since the penetration of the emitted beta particle is very small, the surrounding normal cells are spared.

How is the Therapy Done?

Lu177 PSMA is administered intravenously. The patient is admitted to the hospital for 24 hours. A kidney function scan called a MAG3/EC scan is done prior to the administration of the Lu177 PSMA.

What are the Side Effects of Lu PSMA Therapy?

Lu177 PSMA is well tolerated. The most common side effects are a slightly dry mouth, fatigue and nausea. There may also be a slight fall in the white blood cells and platelets about 2 – 3 weeks after the Lu177 PSMA administration.

What is the Response Rate With Lu PSMA Therapy?

The response rates of Lu177 PSMA depend on the tumour biology of prostate cancer, the initial Gleason Score, the extent of disease and the responses to prior therapies. Typically, more than 70% of patients demonstrate a reduction in S. PSA and a shrinkage of tumours following Lu177 PSMA therapy.

When would the doctor consider using this Therapy?

Lu PSMA Therapy is a very specific therapy and is used for managing metastatic Prostate Cancer or when Prostate Cancer is no longer responsive to other types of treatment.

What are the Treatment Schedules with Lu PSMA Therapy?

Most patients undergo three-four treatment cycles at intervals of 8-12 weeks. The number of cycles and the interim duration may vary between individuals depending on the response and interim assessments.

Why should I choose the nuclear medicine therapy center at Fortis Memorial & Research Institute (FMRI), Gurugram (Haryana, India)?

The Nuclear Medicine Therapy Centre at FMRI was one of the first institutes to offer Radio-ligand Therapy with Lu PSMA, and today, the center receives patients from the country and from across the world.

lutetium-177-prostate-cancer-treatment - nuclearmedicinetherapy.in

Radio-theranostics: How Tiny Radioactive Molecules are Personalising Cancer Care

The term 'theranostics' is an integration of the words 'therapeutics' and 'diagnostics'. Theranostic agents are paired agents, one an imaging agent that 'sees' the lesion and the other, a companion therapeutic agent that 'treats' the same lesions. While the concept of theranostics is widely used in various molecular probes in oncology, the most relevant application of theranostics is in nuclear medicine where it is called Radio-theranostics.

Metastasis directed Lu-177 PSMA Therapy in Prostate Cancer Patients with Oligometastatic Disease

Oligometastatic prostate cancer (OMPC) that has five or fewer sites of metastasis is considered a transitional state between localized and widespread metastatic tumors. With improvements in diagnostic modalities such as functional imaging / PSMA PET-CT, OMPC is being diagnosed with greater frequency than ever before.

My Experience Getting Lu177 PSMA Therapy In India at Fortis Memorial Research Institute (FMRI)

I am a Prostate Cancer patient from USA (name withheld on request). I came to India, specifically to the Department of Nuclear Medicine & Molecular Imaging at Fortis Memorial Research Institute (FMRI) in Gurugram, India. I am writing this blog to share my experience of getting the Lu 177 PSMA (Prostate Specific Membrane Antigen) Therapy.

Lowest Cost of Lu177 PSMA Therapy

For prostate cancer patients who have become refractory to conventional therapy, the department of Nuclear Medicine & Molecular Imaging at the Fortis Memorial Research Institute (FMRI) in India’s Gurugram is not only one of the World’s most advanced Nuclear Medicine Centre but is also the centre that offers the lowest cost for Lu177 PSMA Therapy.

info@nuclearmedicinetherapy.in

+91-98111 27080

Fortis Memorial Research Institute, Sector - 44, Gurgaon, India

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Radio-theranostics: How Tiny Radioactive Molecules are Personalising Cancer Care

Metastasis directed Lu-177 PSMA Therapy in Prostate Cancer Patients with Oligometastatic Disease

My Experience Getting Lu177 PSMA Therapy In India at Fortis Memorial Research Institute (FMRI)

Lowest Cost of Lu177 PSMA Therapy